Mulberry defoliators are considered to be major insect pest as they cause extensive damage to the growth, development and productivity of mulberry. Leaf Webber Diphania pulverulentalis Hamson, Specially its incidence peak in the month of October to December in south India, high percentage of loss due to this pest is around 30%. Cutworm, Spodoptera litura is a polyphagus pest which occurs sporadically on mulberry from in winter season mainly. Peak infestation August to February. Bihar hairy caterpillar, Spilosoma oblique. Peak infestation was seen during March to April and July to November. The loss due to defoliation is up to 40%. Wingless grass hopper, Neorthecris acuticeps nilgirensis, occurs during monsoon and post monsoon periods with peak infestation during October and then declines, to manage these major pests Integrated pest management is well defined tool, by looking at the eco-friendly molecules new generation insecticidal molecules and botanicals showed significant superior result in management