Aldicarb was marketed in Brazil until 2012, when its registration was canceled due to its illegal use as a rodenticide, which favored the occurrence of
serious and fatal poisonings in animals and humans. After oral exposure, aldicarb is absorbed and initially oxidized to aldicarb-sulfoxide and a portion of it slowly degrades to aldicarb-sulfone. The toxicity of aldicarb-sulphoxide is like that of the parent compound, whereas the toxicity for sulfone is much smaller.
Thus, it may be considered that in the case of a single dose exposure, besides the agent itself, the presence of the metabolite formed in the stomach at acidic pH could contribute to potentiatethe toxicity. Therefore, this study proposed to evaluate the dissolution profile of the toxic active principle of the finished form of the granules of this pesticide, using the dissolution profile, to evaluate the in vitro formation of its metabolites in an acid compartment. It was made the kinetics study of release of the toxic active principle of the finished form of the Temik150® granules, using the dissolution profile, to evaluate the
in vitro formation of its metabolites in acidic medium. The method used was high-performance liquid chromatography. The dissolution profile of Temik150® granules in acid medium showed in vitro the presence of the metabolites aldicarb-sulfoxide and aldicarb-sulfone. Since aldicarb-sulfoxide is as toxic as the parent compound, this finding should be considered in suspected poisoning cases.
Aldicarb. Toxicology. Temik150®granules. Metabolite
