Purpose: The aim of this study is to analyse the effects of combination therapy of Bacopa monnieri and topiramate in management of seizures and post seizure depression.
Methods: In this study, the combined effect of these two drugs on seizures and post seizure depression were evaluated and its efficacy were compared with phenytoin the gold standard medication used for managing seizures. Two different formulations were used and their effects were evaluated in mice in Picrotoxin induced animal model for 14 days and Maximal Electroshock model for epilepsy. Several behavioural parameters were conducted to study the effect of drug in managing seizures and other comorbid conditions. GABA levels were also estimated using 2D chromatography.
Results: The results suggests marked reduction in the occurrence of seizure. The formulation with the elevated dose of bacopa monnieri suggested a decrease in the occurrence of seizure/seizure like symptoms along with a significant reduction in post seizure depression.
Conclusion: Thus this combination may prove effective to control seizures as well as post seizure depression.
Seizures, bacopa monnieri, topiramate, picrotoxin, maximal electroshock, GABA.
