Multiple Sclerosis (MS) is an autoimmune neurological disease with etiology and pathogenesis not fully known. Inflammation and neurodegeneration are blamed for the pathogenesis of the disease. MTHFR is a key enzyme with an important role in DNA methylation. In our study we aimed to investigate the
MTHFR C677T and A1298 polymorphism causing enzyme defects in the MTHFR enzyme, responsible for methionine synthesis for axon myelination in the CNS and DNA methylation and important for homocysteine metabolism, and to determine the polymorphism -disease relationship.
The study included a 61-person patient group (41 females and 20 males, mean age 39.37 years) monitored for MS diagnosis and a 121 person healthy control group (50 females and 70 males, mean age 42.94 years). Patients were investigated for MTHFR C677T and A1298C polymorphism and disease association.
There was no statistically significant correlation identified between MS and rs1801131 and rs1801133 alleles.
Genetic polymorphism and disease tendency associations may vary from society to society. In our study we did not identify a correlation between MS disease and MTHFR rs1801131 and rs1801133 genotype polymorphism.
Multiple sclerosis, MTHFR,polymorphism
