ANTICONVULSANT ACTIVITY AND ESTIMATION OF GABA OF COMBINATION OF ANNONA SQUAMOSA, NARDOSTACHYS JATAMANSI AND BACOPA MONNIERI FORMULATION AND EPI CAPS IN MICE

Several studies have indicated the role of Annona squamosa, Nardostachys jatamansi, Bacopa monnieri for its anti convulsant effects individually. Thus a combination of these extracts along with a marketed formulation Epi caps was evaluated for its anti convulsant potency. The combination of extracts was given in 100mg/kg and 200mg/kg for 14 days. The anti convulsant potency of these drugs was evaluated using Pentylenetetrazole and Maximal electroshock models for epilepsy in mice. GABA estimation was performed by paper chromatography. The results evidently suggest that the combination of extracts as well as Epi caps were able to control the extent and severity of seizures in PTZ and MES models