Formulation and evaluation of hydrogel containing tagetes erecta l. leaves etanolic extract

Author: 
Hosea Jaya Edy, Marchaban, Subagus Wahyuono and Agung Endro Nugroho

Hydrogel is quite convenient dosage used in topical therapy. The ethanol extract of Tagetes erecta L. leaves can be used as the active ingredient of hydrogel. The combination of base carbopol, gelatine and Na-CMC can be applied in the manufacturing process.Getting hydrogel with the active ingredient content of extract of T. erecta leaves that have physical properties and good physical stability based on the expected parameters.
Hydrogel base are Carbopol, Gelatine, Na-CMC with the other ingredients are ethanol, propylene glycol, triethanolamine and distilled water. Physical properties tested were organoleptic, pH, spreadability and viscosity. Physical stability testing for 90 days at a temperature of 45°C with 75% RH values using a tool climatic chamber, physical properties testing performed on days 30, 60, and 90th. The resulting hydrogel perfomed on days 0 has good physical properties and the corresponding expected parameters. The resulting physical stability in accelerated stability testing for three months only 5th formula also corresponds the parameters required.

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