Antibiogram profile for staphylococcusaureus and coagulase-negative staphylococci isolates from pregnant women with asymptomatic bacteriuria in nairobi, kenya

Adelaide Ogutu Ayoyi., Gideon Kikuvi., Christine Bii and Samuel Kariuki

Background: Urinary tract infection (UTI) is a condition, which manifest in various forms such as acute, uncomplicated bacterial pyelonephritis, complicated UTI, recurrent cystitis and asymptomatic bacteriuria. Urinary tract infection (UTI) is one of the most frequent types of bacterial infections. The main purpose of this study was to determinate the frequency and antibiogram profile of Staphylococcal spp in urine obtained from pregnant women. This was a cross-sectional study involving 1020 women attending antenatal clinicat selected clinics in Nairobi County. The midstream urine samples were collected and subjected to culture, and sensitivity.The antimicrobial susceptibility profile of Staphylococcus aureus and (CoNS) strains was done using disc diffusion method according to Clinical and Laboratory Standards Institute (CLSI) criteria. 11 antibiotics were used as follows Kanamycin, Gentamycin, Chloramphenicol, and Ampicillin, amoxicillin/clavulanate, Ceftazidine, Tetracycline, Cotrimoxazole, Ciprofloxacin, Cefotaxime and imipenem. During the study 219 urine samples were found to have significant asymptomatic bacteriuria (ASB) and 42.9% of all bacterial isolates were Staphylococcal spp. Multiple antibiotic resistance index (MARI) for isolates ranged from 0.18 to 1.0.Theprevalence of Staphylococcal spp as etiological agents of ASB among sampled pregnant women was 42.9%. They were the most prevalent aetiological agent in this study Therefore, routine screening for gram positive bacteria as etiological agent of ASB should be considered. The MAR index reported in this study is an indication the isolates were from high risk environment

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