The drug toxicity still have interest, most of researches and pharmaceutical companies are playing an important roles to produce safe new drugs and developed the others by using advanced technology. To better understand the safety of gentamox, we used 32 lbino rats divided into 4 groups. The first and second groups injected intramuscularly with gentamox for 3 days and five days respectively. The third group pretreated with vanillin orally at dose of 150 mg/kg for five days then injected intramuscularly with gentamox for five days. The fourth group was used as control group. All rats were sacrificed with gentamox for five days. The fourth group was used as control group. All rats were sacrificed toxicity as lead to significant increased levels of AST ALT, uric acid, creatinine and BUN The most prominent pathological lesion of gentamox was dilated sinusoids filled with blood which called hepatic peliosis which become increased after five days of treatment. Also kidney of gentamox treated rats show hyperemia of both cortex and glomeruli as well as seen in liver peliosis. Notably, vanillin pretreatment abrogated the peliosis and hepatorenal toxicity of gentamox in albino rats
gentamox, hepatorenâl toxicity,peliosis, vanillin, albino rats
